Treatments
Donanemab (Kisunla)
Donanemab is the second FDA-approved amyloid-clearing infusion for early Alzheimer's. Unlike Lecanemab, it stops once amyloid is cleared from the brain.
Updated 2026-02-20
How it works
Donanemab (Kisunla) is a monthly IV infusion that targets amyloid plaques. Trials showed about 35% slower decline over 18 months in patients with low-to-medium tau burden.
Who qualifies
- Confirmed early-stage Alzheimer's.
- Amyloid biomarker positive (PET or CSF).
- Able to attend monthly infusions and frequent MRIs.
- Not on chronic anticoagulation in most clinics.
Frequently asked questions
- Does Medicare cover Kisunla?
- Yes, for eligible patients with amyloid confirmation and ongoing safety monitoring.
- Can I switch from Lecanemab to Donanemab?
- Possible, but the neurologist will weigh ARIA history and tau burden first.
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